Additional file 5: of Targeting the tumor stroma with an oncolytic adenovirus secreting a fibroblast activation protein-targeted bispecific T-cell engager
Antitumor activity of ICO15K-FBiTE. NSG mice bearing subcutaneous xenografts of A549 or HPAC tumors were injected intratumorally with PBS or 2 × 109 viral particles of ICO15K or ICO15K-FBiTE. The mean tumor volume ± SEM of ≥12 tumors per group is shown. *, significant (P < 0.05) by one-way ANOVA test with post hoc analysis compared to ICO15K group. #, significant (P < 0.05) by one-way ANOVA test with post hoc analysis compared to PBS group. (DOCX 195 kb
