Manning, Lanthiena

Peercy, Bradford E

Starz-Gaiano, Michelle

Weideman, Ann Marie

VCU Scholars Compass

Virginia Commonwealth UniversityVCU Scholars CompassBiology and Medicine Through MathematicsConference 2016May 21st, 5:30 PM - 8:00 PMExtracellular Space Geometry Impacts Cell FatePattern Induced by a Diffusible MorphogenBradford E. PeercyUniversity Maryland Baltimore County, bpeercy@umbc.eduLanthiena ManningUniversity Maryland Baltimore CountyAnn Marie WeidemanUniversity Maryland Baltimore CountyMichelle Starz-GaianoUniversity Maryland Baltimore CountyFollow this and additional works at: http://scholarscompass.vcu.edu/bammThis Event is brought to you for free and open access by the Dept. of Mathematics and Applied Mathematics at VCU Scholars Compass. It has beenaccepted for inclusion in Biology and Medicine Through Mathematics Conference by an authorized administrator of VCU Scholars Compass. Formore information, please contact libcompass@vcu.edu.http://scholarscompass.vcu.edu/bamm/2016/May21/33Abstract: Extracellular chemical signaling to determine cell fate is an important function in cell development. The extracellular space then plays a critical role in containing and even diverting such a chemical signal.  We consider an egg chamber from {\it drosophila melanogaster} and the transition of static epithelial cells to motile cells as signaled by the diffusible morphogen, unpaired (UPD).  Central release of UPD beneath the 2D epithelium in uniform extracellular space would tend to produce radially symmetric activation.  However, using novel experimental techniques we find that in greater than half of the cases, radial symmetry is replaced by several other patterns.  We hypothesize that the underlying extracellular geometry defined by neighboring nurse cells diverts UPD and alters the activation pattern.  Patterns predicted from the model have been confirmed in the experimental system.    This work was supported in part by the UBM training grant to UMBC NSF-Grant No. DBI 1031420  

Extracellular Space Geometry Impacts Cell Fate Pattern Induced by a Diffusible Morphogen

http://scholarscompass.vcu.edu/cgi/viewcontent.cgi?article=1042&context=bamm

Extracellular Space Geometry Impacts Cell Fate Pattern Induced by a Diffusible Morphogen

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