Acne vulgaris displays all the characteristics of a polygenic disorder in that hereditary factors are apparent with strong family tendencies for the disorder while the phenotypic expression of the disease varies over a wide spectrum. All that is known for certain concerning the genetics of acne is that concordance is extremely high in identical twins. In the past decade, various investigations have resulted in much clearer concepts of pathogenesis and have brought us to the point of effective therapy for the majority of cases. In this report, I will summarize recent concepts in the pathogenesis of acne vulgaris
