The acquired auto-immune hemolytic anemias represent a diversity of disease states in which the most constant immunologic finding is a positive direct anti-human globulin test (van Loghem, 1965; Swisher et al, 1965). This is true of the symptomatic variety of acquired hemolytic anemia as well as the idiopathic form. The positive Coomb\u27s test has been seen in association with primary atypical pneumonias, occasionally in favism, in some bacterial and drug induced hemolytic anemias, in patients with malignancies of the lymphoid tissues, and in collagen-vascular disorders--chiefly SLE
