George, Uduak

VCU Scholars Compass

Virginia Commonwealth UniversityVCU Scholars CompassBiology and Medicine Through MathematicsConference 2016May 20th, 4:00 PM - 4:30 PMModeling Tracheal Occlusion in the EmbryonicLungUduak GeorgeUniversity of Louisiana Monroe, uduakg@gmail.comFollow this and additional works at: http://scholarscompass.vcu.edu/bammPart of the Developmental Biology CommonsThis Event is brought to you for free and open access by the Dept. of Mathematics and Applied Mathematics at VCU Scholars Compass. It has beenaccepted for inclusion in Biology and Medicine Through Mathematics Conference by an authorized administrator of VCU Scholars Compass. Formore information, please contact libcompass@vcu.edu.http://scholarscompass.vcu.edu/bamm/2016/May20/7Modeling Tracheal Occlusion in the Embryonic Lung  Uduak Z. Georgea, Kishore K. Bokkab, David Warburtonc, Sharon R. Lubkinb  a University of Louisiana Monroe, 700 University Avenue, Monroe, LA 71209, USA b North Carolina State University, Raleigh, NC 27695-8205, USA c Saban Research Institute, 4650 Sunset Boulevard, MS# 35, Los Angeles, CA 90027, USA  Abstract  Prenatal tracheal occlusion has different effects on a developing lung and depends on the stage of development. It enhances lung growth when performed in near-term fetus. Laboratory experiments have shown that tracheal occlusion of the embryonic lung increases the rate of lung branching by 2-to 3-fold in mouse models. Tracheal occlusion leads to retention of fluid in the lung and increases the pressure in the lumen. The mechanism by which tracheal occlusion accelerates lung branching is not fully understood. In order to study the effects of increased lumen pressure and fluid retention on lung branching, we develop a linear elastic model and a solute transport model in a three-dimensional lung geometry. The finite element method is used to obtain numerical solutions. Results from numerical simulations show that blocking the outflow of fluid may alter the distribution patterns of morphogen transport and binding thus, increasing the number of locations at which branches are induced.    

Modeling Tracheal Occlusion in the Embryonic Lung

http://scholarscompass.vcu.edu/cgi/viewcontent.cgi?article=1059&context=bamm

Modeling Tracheal Occlusion in the Embryonic Lung

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