A Selective and Convenient Method for the Synthesis of 2-Phenylaminothiazolines

Abstract

A series of 2-phenylaminothiazolines have been prepared from the corresponding N-(2-hydroxyethyl)-N′-phenylthioureas under mild reaction conditions using either thio-CDI (1,1′-thiocarbonyldiimidazole) or CDI (1,1′-carbonyldiimidazole) to promote the cyclization. This protocol provides the desired cyclization products in good yield with excellent selectivity. The scope and selectivity of this methodology are also described