Genetic network detailing the types of interactions between a subset of the 94 candidate genes.

Abstract

<p>Genes associated (empirical p<0.01) with at least one neurophysiological phenotype (PPI, startle habituation, and P50 S1) are highlighted in yellow in (<b>A</b>), and genes associated (empirical p<0.01) with the neurocognitive phenotypes (antisaccade, LNS forward, LNS re-order, CVLT-II immediate recall, CVLT-II delayed recall, WCST-64 perseverative responses, or WCST-64 categories) are highlighted in (<b>B</b>). Note that antisaccade was grouped with the neurocognitive phenotypes based on its demonstrated correlations with these measures (see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0029630#pone-0029630-t002" target="_blank">Table 2</a>). Genes are represented as nodes, and the biological relationship between two nodes is represented as an edge (line or arrow) supported by at least one reference from the literature, a textbook, or canonical information derived from the human, mouse, and rat orthologs of the gene that are stored in the Ingenuity Pathways Knowledge Base. Solid and dashed lines/arrows indicate direct and indirect interactions, respectively.</p