Immunohistochemical staining for COUP-TF1 in human prostate cancer, high grade PIN and benign epithelium.

Abstract

<p>A. Immunohistochemical staining of human prostate cancer samples and adjacent benign glands for COUP-TF1 shows a nucleolar distribution of COUP-TF1 in malignant cells (upper left) and no COUP-TF1 staining in the adjacent benign gland (lower right). Stromal cells show nuclear staining of COUP-TF1. A representative of 28 samples analyzed is shown. B. Prostatic Intraepithelial Neoplasia (PIN) shows nucleolar distribution of COUP-TF1 and adjacent stromal cells show nuclear staining. C. immunostaining of LAPC4 xenografts shows nucleolar COUP-TF1 staining.</p