Conduction velocities and changes in regional <i>I</i>_Na in cardiomyocytes in each myofiber model.

Abstract

<p>(A) and (B), Relative ratios of CV (%CV) normalized by CV in the myocardial fiber with 50%<i>g</i>_Na,JM and 50%<i>g</i>_Na,LM as a function of %<i>g</i>_Na,JM or %<i>g</i>_Na,LM in the cleft (A) and non-cleft (B) models. (C), Peak values of post-junctional <i>I</i>_Na (post-<i>I</i>_Na,JM), pre-junctional <i>I</i>_Na (pre-<i>I</i>_Na,JM), and lateral <i>I</i>_Na (<i>I</i>_Na,LM) in a myocyte in the cleft model in which the Na⁺ channels are fixed at 50%<i>g</i>_Na,JM with 50%<i>g</i>_Na,LM, 30%<i>g</i>_Na,LM, or 10%<i>g</i>_Na,LM (<i>left</i>) and at 50%<i>g</i>_Na,LM with 50%<i>g</i>_Na,JM, 30%<i>g</i>_Na,JM, or 10%<i>g</i>_Na,JM (<i>right</i>). (D), Peak values of post-<i>I</i>_Na,JM, pre-<i>I</i>_Na,JM, and <i>I</i>_Na,LM in a myocyte in the non-cleft model with 50%<i>g</i>_Na,JM and 50%<i>g</i>_Na,LM, 30%<i>g</i>_Na,LM, or 10%<i>g</i>_Na,LM (<i>left</i>), and 50%<i>g</i>_Na,LM with 50%<i>g</i>_Na,JM, 30%<i>g</i>_Na,JM, or 10%<i>g</i>_Na,JM (<i>right</i>). The peak values of <i>I</i>_Na in each membrane segment were measured in the middle of the myofiber.</p