<p>Heatmaps showing differentially expressed genes for early vs. late passage <b>(A)</b>, mechanical vs. enzymatic passage <b>(B)</b>, and Mef vs. Ecm substrate <b>(C)</b>. In heatmap <b>(A)</b>, the yellow boxes indicate genes for which the expression levels in the late passage MefMech (P103) samples was similar to those in the early passage samples. Probes were selected by multivariate regression. Enrichments in KEGG pathways identified by functional enrichment analysis are shown. Samples were arranged according to passage and culture method, and hierarchical clustering was performed on the genes only. <b>D</b>. Diagram of the TP53 signaling pathway, showing genes downregulated in the late vs. early passage samples, and the Ecm vs. Mef substrate comparisons.</p
