Conversion of astrocytes into neuronal cells which did not pass through the pluripotent stage.

Abstract

<p><b>(A)</b> Expressions of Oct4 and Nanog genes as pluripotent markers were not detected following miR-302/367+ valproic acid (VPA) treatment. n = 3. Scale bar: 50 μm. (B) The brain tissue of animals treated with the miR-302/367 cluster were investigated for the teratoma formation. No teratoma formation was observed at 60 days post-injection (dpi). n = 2. Scale bar: 50 μm.</p