Bindslev-Jensen, Carsten

Halken, Susanne

Karaman, Ozkan

Uysal, Pınar

Uzuner, Nevin

Clinical and Translational Allergy

PubMed

Syddansk Universitets Forskerportal

PD40 - A successful desensitisation to cat in a child with anaphylaxis

Pınar Uysal

Carsten Bindslev-Jensen

Nevin Uzuner

Özkan Karaman

Susanne Halken

Springer - Publisher Connector

POSTER DISCUSSION PRESENTATION Open Access
PD40 - A successful desensitisation to cat in
a child with anaphylaxis
Pınar Uysal1*, Carsten Bindslev-Jensen2, Nevin Uzuner3, Özkan Karaman3, Susanne Halken4
From 3rd Pediatric Allergy and Asthma Meeting (PAAM)
Athens, Greece. 17-19 October 2013
Introduction
Allergic sensitization to airborne cat allergens is com-
mon and mostly related with asthma and allergic rhini-
tis. Anaphylactic reactions due to exposure to cats have
not been reported. Herein, we report the case of 8-year-
old boy who had experienced anaphylaxis after contact
with cats and successfully desensitized in the first year of
immunotherapy.
Case report
He was referred with a history of suddenly occurring
sneezing, urticaria, respiratory distress, wheezing and
sometimes hypotension within 30 minutes after contact
with cats. He had experienced those symptoms more
than five times with a variety of severity in last two
years. His past medical history was insignificant for
asthma or any of atopic diseases. Allergen specific IgE
against cat was 24 kUA/L, and negative against dog and
other furred animal dander by ImmunoCAP assay®
(Phaida Diagnostics, Uppsala, Sweden). Skin prick test
(SPT) was 5 mm for histamine, 11 mm for commercial
extract of cat dander and negative for other animal dan-
der and pollens. With regard to unconvincing history,
an open challenge test was performed at hospital setting.
Anaphylactic reaction with sneezing, rhinorrhea, diffuse
urticaria, coughing and mild hypotension developed
within 20 minutes after exposure to cat. A subcutaneous
immunotherapy protocol was designed with a built-up
phase of 6 months. He had no systemic reaction during
immunotherapy except large local allergic reactions at
injection site at built-up phase. He was evaluated for
desensitization at the first year of immunotherapy by a
skin prick test and provocation test without any local or
systemic allergic reactions.
Conclusion
For the first time, by presenting this case anaphylactic
reactions mediated by exposure to airborne cat allergens
is demonstrated to underline the causative role of inha-
lant allergens in development of anaphylaxis. Moreover,
a successful desensitization to cat allergens in a child
with anaphylaxis was established in the first year of
immunotherapy.
Authors’ details
1Department of Pediatrics, Division of Allergy and Immunology, Adnan
Menderes University Hospital, Aydın, Turkey. 2Department of Dermatology
and Allergy Centre, Odense University Hospital, Odense, Denmark.
3Department of Pediatrics Division of Allergy and Immunology, Dokuz Eylul
University Medical Faculty, Izmir, Turkey. 4Hans Christian Andersen Children’s
Hospital, Odense University Hospital, Odense, Denmark.
Published: 28 February 2014
doi:10.1186/2045-7022-4-S1-P40
Cite this article as: Uysal et al.: PD40 - A successful desensitisation to
cat in a child with anaphylaxis. Clinical and Translational Allergy 2014
4(Suppl 1):P40.
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1Department of Pediatrics, Division of Allergy and Immunology, Adnan
Menderes University Hospital, Aydın, Turkey
Full list of author information is available at the end of the article
Uysal et al. Clinical and Translational Allergy 2014, 4(Suppl 1):P40
http://www.ctajournal.com/content/4/S1/P40
© 2014 Uysal et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons
Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction
in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver
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PD40 - A successful desensitisation to cat in a child with anaphylaxis

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