Pusat Pengajian Sains Perubatan, Universiti Sains Malaysia
Abstract
We studied three different target blood concentrations (TBC) of propofol for
induction of anaesthesia using target controlled infusion (TCI) technique. One hundred
and thirty five ASA I and II patients, between 18-55 years of age and undergoing any type
of elective surgery were included in the study. All patients were premedicated with oral
midazolam 7.5 mg in the ward an hour before induction. Patients were randomly divided
into three groups. Group I (n = 45) received initial TBC of 2 J,Jg/ml, group II (n = 45) TBC
of 3 J.Jg/ml and group Ill (n = 45) TBC of 4 J,Jg/ml for induction of anaesthesia. Intravenous
alfentanil 30 ~g/kg bolus was given as analgesia. Patients were observed for success
rate of induction, induction time, effect site concentration and haemodynamic parameters
at baseline, 1 minute, 3 minutes and 5 minutes after induction.
Success rate of induction was 55.6 %, 86.7% and 91.1 %in group I, 11 and 111
respectively, which showed significant difference only between group I and Ill. Effect site
concentration was 0.6 ~g/ml, 0.9 J,Jg/ml and 0.8 JJQ/ml in group I, II and Ill respectively
which showed significant difference only between group I and II. There was no significant
difference in induction time and haemodynamic parameters among the three groups.
Hence, TBC 3 J,Jg/ml was comparable with TBC 4 J.Jg/ml for induction of
anaesthesia using TCI technique. However TBC 2 IJQ/ml was not recommended for rapid
induction
