In this study emulsions with varying ratios of surfactant or its mixtures (Tween 80®,
Tween 85® and Span 20®) were prepared using POE as the oil phase. The
transparency of the mixtures was used as visual indications that nano-emulsions were
formed and were reconfirmed by measuring the droplets size using laser scattering
spectroscopy (Nanophox). The gel area of the triangle phase diagrams produced was
used as one of criteria to determine the suitable HLB value of the nano-emulsion’s
emulsifier for POE and for selection of several promising formulae. It was noted that
largest gel area produced by HLB 15, 13.72 and 12. From these three phase diagrams
three common points namely A, B and C were selected and mixtures of POE and
surfactant constituted in them were used to study the solubility of ketoprofen
