Alzheimer’s disease (AD) is a primary cause of dementia in the middle-aged and elderly
worldwide. Animal models for AD are widely used to study the disease mechanisms as well as to
test potential therapeutic agents for disease modification. Among the non-genetically
manipulated neuroinflammation models for AD, lipopolysaccharide (LPS)-induced animal
model is commonly used. This review paper aims to discuss the possible factors that influence
rats’ response following LPS injection. Factors such as dose of LPS, route of administration,
nature and duration of exposure as well as age and gender of animal used should be taken into
account when designing a study using LPS-induced memory impairment as model for AD
