A Liberati

AB Nathens

AJ Bastin

AM de Smet

BH Cuthbertson

CM Vandenbroucke-Grauls

DK Heyland

FF Sniehotta

I Ajzen

I Seppelt

J Francis

J Grimshaw

JC Hurley

JE McKenzie

JJ Francis

K Krippendorff

L MacIntyre

L Silvestri

M Eccles

MH Kollef

MK Campbell

R D'Amico

R Redman

R Shah

RB Akins

S Hrisos

S Michie

Selective Decontamination of the Digestive Tract Trialists' Collaborative Group

Trials

English

PubMed

Cuthbertson, B H

Francis, J

Campbell, M K

MacIntyre, L

Seppelt, I

Grimshaw, J

SuDDICU study groups

Aberdeen University Research

A: “Psychological Theory” Group: Making psychological theory useful for implementing evidence based practice: a consensus approach. Quality & Safety in Health Care

A: Effectiveness of antibiotic prophylaxis in critically ill adult patients: systematic review of randomised controlled trials. BMJ

A: Selective decontamination of the digestive tract reduces bacterial bloodstream infection and mortality in critically ill patients. Systematic review of randomized, controlled trials. J Hosp Infect

Action planning and coping planning for long-term lifestyle change: theory and assessment.

Analysis of respiratory and nonrespiratory infections in published trials of selective digestive decontamination [abstract]. Intensive Care Medicine

Antibiotic prophylaxis to reduce respiratory tract infections and mortality in adults receiving intensive care. [update of Cochrane Database Syst Rev. 2000;(4): CD000022; PMID: 11034667]. Cochrane Database of Systematic Reviews

Bonten MJ: Decontamination of the digestive tract and oropharynx in ICU patients.

Changing clinical behaviour by making guidelines specific. BMJ

Cole BR: Stability of response characteristics of a Delphi panel: application of bootstrap data expansion.

Content analysis: An introduction to its methodology.

Developing the content of two behavioural interventions. Using theorybased interventions to promote GP management of upper respiratory tract infection without prescribing antibiotics.

E: Translating clinicians’ beliefs into implementation interventions (TRACII): a protocol for an intervention modeling experiment to change clinicians’ intentions to implement evidence-based practice. Implementation Science

From theory to intervention: mapping theoretically derived behavioural determinants to behaviour change techniques. Special Issue on “Conceptualizing TheoryBased Health Behavior Change Research” of Applied Psychology: an international review

Guyatt GH: Selective decontamination of the digestive tract. An overview. Chest

Impact of selective decontamination of the digestive tract on fungal carriage and infection: systematic review of randomized controlled trials. Intensive Care Med

JC: Selective decontamination of the digestive tract in surgical patients: a systematic review of the evidence. Archives of Surgery

Prophylaxis with enteral antibiotics in ventilated patients: selective decontamination or selective cross-infection? Antimicrobial Agents & Chemotherapy

Ryanna KB: Use of selective decontamination of the digestive tract in United Kingdom intensive care units. Anaesthesia

SE: IMPLEmenting a clinical practice guideline for acute low back pain evidence-based manageMENT in general practice (IMPLEMENT): cluster randomised controlled trial study protocol. Implementation Science

Selective Decontamination of the Digestive Tract Trialists’ Collaborative Group: Meta-analysis of randomised controlled trials of selective decontamination of the digestive tract. BMJ

Stanworth SJ: Evidence-based selection of theories for designing behaviour change interventions: Using methods based on theoretical construct domains to understand clinicians’ blood transfusion behaviour.

T: National survey on current practice of use of selective digestive decontamination in the United Kingdom [abstract]. Critical Care

Testing a TheoRY-inspired MEssage (’TRY-ME’): a sub-trial within the Ontario Printed Educational Message (OPEM) trial [Registration number ISRCTN72772651]. Implementation Science

The institute of health care improvement; critical care: [http://www.ihi.org/ IHI/Topics/CriticalCare/],

The institute of health care improvement; critical care: [http://www.ihi.org/ IHI/Topics/CriticalCare/], Accessed on 9th

The role of selective digestive tract decontamination on mortality and respiratory tract infections. A meta-analysis. Chest

The Scottish Patient safety alliance: [http://www.patientsafetyalliance.scot. nhs.uk/programme/],

The Theory of Planned Behavior. Organizational Behaviour and Human Decision Processes

Vandenbroucke JP: Effect of selective decontamination of the digestive tract on respiratory tract infections and mortality in the intensive care unit. Lancet

A study of the perceived risks, benefits and barriers to the use of SDD in adult critical care units (the SuDDICU study)

BACKGROUND: Hospital acquired infections are a major cause of morbidity and mortality and markedly increased health care costs. Critically ill patients who require management in an Intensive Care Unit are particularly susceptible to these infections which are associated with a very high mortality. Selective decontamination of the digestive tract (SDD) may reduce these infections and improve mortality but it has not been widely adopted into practice. We aim to 1. Clarify reasons why clinicians have avoided implementing SDD into clinical practice despite the current best-evidence 2. Describe barriers to SDD implementation and 3. Identify what further evidence is required before full scale clinical implementation would be considered appropriate and feasible. METHODS: We have developed an international 'multi-lens' approach to investigate SDD from several perspectives. In case studies we will identify accounts of implementation of SDD in practice, in terms of the behaviours performed by the full range of individual clinicians, accounts of how SDD was first introduced into the Unit and specific content that may be used to populate the content of behaviour change techniques to be used in an implementation intervention and procedures to consider in order to deliver an implementation trial. In a 4 round Delphi study we will identify the range of stakeholders' beliefs, views and perceived barriers relating to the use of SDD. We will generate hypotheses about key beliefs about SDD and will inform the feasibility of any future randomised controlled trial. In large-scale nationwide postal questionnaire surveys of the state of current practice we will identify the factors predicting acceptability of an effectiveness or implementation trial using, and informed by, the theoretical domains structure. In semi-structured interviews with active international clinical trialists we will assess the feasibility of a randomised controlled trial and identify challenges and barriers to undertaking research in the field of SDD research. DISCUSSION: We believe these methods will allow us to determine whether clinical implementation trials or further large effectiveness trials are required before full scale implementation into clinical practice

Cuthbertson, BH

Campbell, MK

University of Melbourne Institutional Repository

A study of the perceived risks, benefits and barriers to the use of SDD in adult critical care units (The SuDDICU study)

null null

Springer - Publisher Connector

Crossref

Background-: Hospital acquired infections are a major cause of morbidity and mortality and markedly increased health care costs. Critically ill patients who require management in an Intensive Care Unit are particularly susceptible to these infections which are associated with a very high mortality. Selective decontamination of the digestive tract (SDD) may reduce these infections and improve mortality but it has not been widely adopted into practice. We aim to 1. Clarify reasons why clinicians have avoided implementing SDD into clinical practice despite the current best-evidence 2. Describe barriers to SDD implementation and 3. Identify what further evidence is required before full scale clinical implementation would be considered appropriate and feasible.



Methods-: We have developed an international ‘multi-lens’ approach to investigate SDD from several perspectives. In case studies we will identify accounts of implementation of SDD in practice, in terms of the behaviours performed by the full range of individual clinicians, accounts of how SDD was first introduced into the Unit and specific content that may be used to populate the content of behaviour change techniques to be used in an implementation intervention and procedures to consider in order to deliver an implementation trial. In a 4 round Delphi study we will identify the range of stakeholders’ beliefs, views and perceived barriers relating to the use of SDD. We will generate hypotheses about key beliefs about SDD and will inform the feasibility of any future randomised controlled trial. In large-scale nationwide postal questionnaire surveys of the state of current practice we will identify the factors predicting acceptability of an effectiveness or implementation trial using, and informed by, the theoretical domains structure. In semi-structured interviews with active international clinical trialists we will assess the feasibility of a randomised controlled trial and identify challenges and barriers to undertaking research in the field of SDD research.



Discussion: We believe these methods will allow us to determine whether clinical implementation trials or further large effectiveness trials are required before full scale implementation into clinical practice

Cuthbertson, B. H.

Francis, J.

Campbell, M. K.

Seppelt, I.

Macintyre, L.

Grimshaw, J. M.

City Research Online

Abstract Background- Hospital acquired infections are a major cause of morbidity and mortality and markedly increased health care costs. Critically ill patients who require management in an Intensive Care Unit are particularly susceptible to these infections which are associated with a very high mortality. Selective decontamination of the digestive tract (SDD) may reduce these infections and improve mortality but it has not been widely adopted into practice. We aim to 1. Clarify reasons why clinicians have avoided implementing SDD into clinical practice despite the current best-evidence 2. Describe barriers to SDD implementation and 3. Identify what further evidence is required before full scale clinical implementation would be considered appropriate and feasible. Methods- We have developed an international 'multi-lens' approach to investigate SDD from several perspectives. In case studies we will identify accounts of implementation of SDD in practice, in terms of the behaviours performed by the full range of individual clinicians, accounts of how SDD was first introduced into the Unit and specific content that may be used to populate the content of behaviour change techniques to be used in an implementation intervention and procedures to consider in order to deliver an implementation trial. In a 4 round Delphi study we will identify the range of stakeholders' beliefs, views and perceived barriers relating to the use of SDD. We will generate hypotheses about key beliefs about SDD and will inform the feasibility of any future randomised controlled trial. In large-scale nationwide postal questionnaire surveys of the state of current practice we will identify the factors predicting acceptability of an effectiveness or implementation trial using, and informed by, the theoretical domains structure. In semi-structured interviews with active international clinical trialists we will assess the feasibility of a randomised controlled trial and identify challenges and barriers to undertaking research in the field of SDD research. Discussion We believe these methods will allow us to determine whether clinical implementation trials or further large effectiveness trials are required before full scale implementation into clinical practice.</p

Seppelt I

MacIntyre L

Francis J

Campbell MK

Cuthbertson BH

Grimshaw J

Directory of Open Access Journals

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A study of the perceived risks, benefits and barriers to the use of SDD in adult critical care units (the SuDDICU study)

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