Female participation in the formal sector is gradually growing in hitherto male and female oriented organizations around the globe.However, the rate of female entry into higher positions of management is not encouraging relative to the number of able female labour force in the Nigeria. Using regression analysis on 368 surveys of female academic staff of Nigerian universities via statistical package for social sciences 18, this study examines predictors and found that level of education and organizational support were positively significant to career advancement. However, work experience was negatively related to career advancement. Thus, this is an insight that these positive factors are viable predictors to career advancement of female academic staff. Recommendation for future study was given in the study