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壳聚糖季铵盐表面修饰对载紫杉醇PLGA微球体外药效学的影响
Authors
吕丕平
朱宝成
+3 more
王连艳
蔡明明
马光辉
Publication date
1 January 2012
Publisher
Abstract
采用聚(乳酸羟基乙酸)共聚物(PLGA)纳微球装载紫杉醇,并用壳聚糖季铵盐(HTCC)对PLGA微球表面进行镀层修饰,比较了修饰前后载药微球的形貌、粒径、电位、载药率、释药行为和细胞杀伤效果.结果表明,修饰后微球表面圆整光滑,平均粒径为882nm,载药率可达5.15%,包埋率达70.46%,体外释药22d累积释药率为70.17%,与修饰前没有显著性差异;但修饰后微球表面电荷由修饰前的14.8mV翻转为+36.7mV,肿瘤细胞对PLGA和HTCC-PLGA载药微球的内吞量分别是Taxol的5.6和9.7倍,且HTCC-PLGA载药微球对细胞杀伤效果显著,是一种有潜力的难溶性药物递送系统
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Institutional Repository of Institute of Process Engineering, CAS (IPE-IR)
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Institutional Repository of Institute of Process Engineering, CAS (IPE-IR)
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Last time updated on 09/11/2016