Low postprandial blood glucose is associated with low risk of metabolic diseases. An ability of meal to diminish the glucose response to carbohydrates eaten during the following meal is known as the “second‐meal effect”. The reduced glycemia elicited by low glycemic index foods consumed during the first meal has been suggested as the main mechanism for second‐meal effect. D‐Psicose is a sweet monosaccharaide that provides no energy to growing rats and leads to less glycemic response induced by other carbohydrates. In this study, we examined the second‐meal effect of D‐psicose in rats. Twenty‐eight male Wistar rats (6 weeks old) were fed the first meals (dextrin or CE‐2 with 10% D‐psicose) at 9:00 and then they were fed the second meals (dextrin or CE‐2 without D‐psicose) at 14:00. Plasma glucose concentration was measured for 3‐hours after second ingestion of test meals. However, glycemic responses after second meals did not differ regardless of composition of the first meals. In conclusion, the present study found no second‐meal effect of D‐psicose in rats.departmental bulletin pape
