The paper investigates the importance of territorial characteristics/assets (i.e. agglomeration economies, urban infrastructure, factors of labor and cost, development policies, qualitative factors, inter alia) on small- and medium-sized firms’ competitiveness. The analysis uses primary data from 204 small- and medium-sized firms located in Thessaloniki (Greece). These firms operate in the sectors of industry, commerce and services. Through the use of Structural Equation Modeling (SEM) analysis, the importance of particular factors for the competitiveness of firms has been analyzed, coming out in valuable conclusions not only for the firms and the city of Thessaloniki considered but also for firms and areas with similar characteristics in Greece and the wider area of Balkans
