SaniRegio is an econometric model, based on fixed effects panel techniques, that investigates the level of efficiency of Italian Regions in governing their health care systems. As a result of the model, we obtain a measure of the efficient or standardized expenditure that may be compared to the effective expenditure. The different degree of efficiency on the side of expenditure is finally commented taking into account also the different degree of quality of Italian Regions in offering health care provisions to their citizens