Nevus of Ota is a benign pigmentation disorder that commonly affects areas of the skin and eye supplied by the ophthalmic and maxillary branches of the trigeminal nerve. It typically presents as blue-black or gray macules, mainly in individuals with darker skin tones, and can cause significant cosmetic concerns. Treatment options include cryotherapy, dermabrasion, and laser therapy, with the Q-switched (QS) Nd:YAG (1064 nm) laser emerging as a promising option. This report describes the case of a 25-year-old woman diagnosed with unilateral nevus of Ota. After clinical examination, the patient was treated with the QS Nd:YAG laser, undergoing 12 treatment sessions over three years. A significant reduction in pigmentation was observed with no adverse effects. This case demonstrates the effectiveness of the QS Nd:YAG laser in managing nevus of Ota and highlights the importance of appropriate laser settings, patient selection, and post-treatment care. Laser therapy, particularly with the QS Nd:YAG laser, may offer a reliable and durable solution for reducing pigmentation and improving the cosmetic appearance of patients with this condition
