Filiptsova, O.

Kobets, Yu.

Timoshyna, I.

English

eLibrary National Mining University

169There are lots of challenges and opportunities for marketing services inhospitality industry, as their activity in most cases is built on intagible things, butthey are very significant and valuable for companies and their clients.Timoshyna I., Kobets Yu., Filiptsova O.National University of PharmacyPHENYLTHIOCARBAMIDE SENSITIVITY AS A COST-EFFECTIVEGENETIC TEST FOR STATE OF HEALTH ASSESSMENTA taste sensitivity to phenylthiocarbamide is one of the classical human geneticmarkers. Phenylthiocarbamide (PTC) is felt bitter in some individuals (tasters) andtasteless in others (non-tasters). The ability to sense this substance is highlycorrelated with the ability to sense other bitter compounds of natural origin, many ofwhich are toxic and some are very useful. Most studies indicated monogenic natureof sensitivity to PTC, and this was proved by molecular genetics.PTC is of great interest from the medical point of view, since a number ofassociations of taster status with human diseases is determined. In this connection,sensitivity to PTC defined in the young age may be a predictor of a number ofpathological conditions, including genetically determined (multifactorial), whichdevelopment in individuals in the risk group can be prevented by optimally selectedenvironmental factors. Cheapness and availability of this type of testing appearattractive in the way of diagnostic. The following examples illustrate the diversity ofassociations of sensitivity to PTC. In particular, early studies ascertained theinhibitory activity of PTC regarding tyrosinase. In particular, among non-tasters therewere more individuals with pathology of the thyroid gland as compared with tasters.In one of the studies it was shown that the frequency of PTC non-tasters amongindividuals with idiopathic and symptomatic epilepsy was higher than in the control.In another study non-tasters were more frequently found among patients withschizophrenia, although according to other authors, this relationship was notconfirmed. A higher threshold of sensitivity as to PTC and to sucrose ofschoolchildren was associated with a higher risk of dental caries. Among adults non-tasters there was indicated an increased inclination to obesity. Among children withobesity there were 72% of non-tasters, while among children with normal weight –only 28%. At the same time non-tasters as compared with tasters were lesssusceptible to malaria and they had less high level of anxiety. The connectionbetween sensitivity to PTC and rheumatoid arthritis was studied, but was not proved.Our research has shown that among Ukrainians about 22% individuals can notfeel bitter taste of PTC. Early determination of PTC sensitivity status can be usefuland cheap tools in the prognosis of different health conditions in humans, in the caseof its associations in specific populations, including the population of Ukraine.

PHENYLTHIOCARBAMIDE SENSITIVITY AS A COST-EFFECTIVE GENETIC TEST FOR STATE OF HEALTH ASSESSMENT

http://ir.nmu.org.ua//bitstream/123456789/146820/1/TimoshynaIKobetsYuFiliptsovaO.pdf

PHENYLTHIOCARBAMIDE SENSITIVITY AS A COST-EFFECTIVE GENETIC TEST FOR STATE OF HEALTH ASSESSMENT

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