Predicted metabolic drug clearance with increasing adult age
- Publication date
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- Wiley-Blackwell
Abstract
Conclusion: Decreased metabolic clearance in the elderly was predicted by Simcyp® and was generally consistent with limited clinical data for four out of five drugs studied and the broader literature for drugs metabolized by CYP enzymes. IVIVE-PBPK may be increasingly useful in predicting metabolic drug clearance in the elderly.