National audienceWe present a probabilistic model allowing uncertainties induced by modeling errors and system-parameter uncertainties to be taken into account for a multi-layer composite sandwich panel. The sensitivity of the internal noise inside a bounded cavity coupled with the panel is analyzed with respect to uncertainties. Eight composite panels have been constructed by using the same manufacturing process. Experimental measurements of the vibration and acoustic responses have been performed in the low- and medium- frequency ranges. These measurements allow the probabilistic model of uncertainties to be identified.We present the probabilistic numerical model and its comparison with the experiments for validation