Even though it is well known that quality, safety, and patient-centeredness of
health care can be improved, leveraging the organizational apparatus of a care delivery
environment to render improvement in a consistent and comprehensive manner has proven
difficult. The Health Care Systems Research Network (HCSRN), which began as the HMO
Research Network, emerged from a desire to improve health and study problems in health
care in a systematic and collaborative way, spurring the delivery of true
evidence-informed medicine. The HCSRN has honed network-wide data resources, a
collaborative culture, and shared infrastructure, enabling multicenter health care
research that is often more difficult for researchers working in less integrated
settings and across organizational boundaries. The HCSRN’s 25-year track record confers
both an opportunity and obligation to share what we have learned through our research.
Considering the quarter-century since the HCSRN was established, we describe three
evolving areas—health data, new health care models, and diversified research teams that
must be thoughtfully harnessed to realize a transformed health care ecosystem that
generates and learns with research.</jats:p