ISBN 978-1-49-51-6286-2International audienceA dynamic simulation of coupled supply and demand of energy, resources and nuclear reactors is done with the global model Prospective Outlook for Long Term Energy Supply (POLES) over this century. In this model, both electricity demand and uranium supply are not independent of the cost of all base load electricity suppliers. Uranium consuming Thermal Neutron Reactors and future generation, free from the uranium market once started, breeder reactors are only one part of the market and are in a global competition, not limited to the other nuclear generation. In this paper we present a new model of the impact of uranium scarcity on the development of nuclear reactors. Many scenarios rely on the subjective definition of ultimate uranium resources. We suggest that when uranium will mainly be extracted together with other resources, its cost should not be simply a function of cumulated uranium mined but also of mine yearly outputs. We describe the sensitivities of our model to breeder reactor physical performance indicators. Used fuels can be seen as a liability or as a source of usable material and a scarce resource limiting fast reactor startups in fast development in India or China. We present the impact of synergetic strategies where countries with opposite strategies share used fuels