Baumbach, Jörg Ingo

Buchinger, H.

Kreuder, A.-E.

Kreuer, S.

Maddula, Sasidhar

Rupp, Kathrin

Volk, T.

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CharacterizaƟ on of Opiates in Human Breath of PaƟ ents within Intensive Care Units* Korea InsƟ tute of Science and Technology Europe ForschungsgesellschaŌ  mbH (KIST Europe)Campus E 7 1 - 66123 Saarbrücken - Germanyphone + 49 (0) 681 9382 229   -   fax + 49 (0) 681 9382 240hƩ p://www.kist-europe/r_cd_jibb.htmlhƩ p://www.kist-europe.comhƩ p://www.kist-europe.deContact:    PD Dr. Jörg Ingo Baumbach                   Head of Department Microfl uidics and Clinical DiagnosƟ cs                   baumbach@kist-europe.dePart of a IMS-Chromatogram  of human breathA.-E. Kreuder1,2, H. Buchinger3, S. Kreuer3, Th. Volk3, K. Rupp1, S. Maddula1, J.I. Baumbach11 KIST Europe, Department Microfl uidics and Clinical DiagnosƟ cs, Campus E 71, 66123 Saarbrücken, Germany2 Saarland University, 66123 Saarbrücken, Germany3 Department of Anaesthesiology, CriƟ cal Care and Pain Medicine at Saarland University Hospital, Building 57, 66421 Homburg, GermanyAcknowledgementsThe fi nancial support of the Ministry of EducaƟ on, Science and Technology (MEST) of the Republic Korea is acknowledged thankfully. Part of the work on this paper has been supported by Deutsche For-schungsgemeinschaŌ  (DFG) within the CollaboraƟ -ve Research Center (Sonderforschungsbereich) SFB 876 „Providing InformaƟ on by Resource-Constrai-ned Analysis“, project TB1 “Resource-Constrained Analysis of Spectrometry Data“.In addiƟ on, the work was supported partly by the German Federal Ministry of Economics and Tech-nology based on a decision of the German Bundes-tag within the project KF2368102AKO.Ion mobility spectrometry coupled to a mulƟ -capillary column (MCC/IMS) was used in anesthesia to detect signals related to opioids in the breath directly.Besides the successful determinaƟ on of Propofol at concentraƟ on levels with relevance for applicaƟ ons in the operaƟ onal theatre the detecƟ on of opio-ids in human breath should be considered. We selected Fentanyl, Sufentanil, Remifentanil, Piritramide and Pethidine for measurements in the breath of paƟ ents using BioScout. UltivaResults of measurements of Opiates in the breath of paƟ ents obtained in the operaƟ on room direct-ly and of validaƟ ons in the laboratory in-cluding GC/MSD reference invesƟ gaƟ ons will be presented.Analyzing opioids in breath using MCC/IMS takes the potenƟ al of conƟ nuous applicaƟ on in intensive care.FentanylPropofol

Characterization of Opiates in Human Breath of Patients within Intensive Care Units

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Characterization of Opiates in Human Breath of Patients within Intensive Care Units

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