Baumbach, Jörg Ingo

Cumeras, R.

Favrod, P.

Maddula, Sasidhar

Rupp, Kathrin

Schneider, T.

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INFLUENCE OF ROOM AIR AND OPERATIONAL BACKGROUNDEMISSIONS ON BREATH ANALYSIS USING MCC/IMS* Korea InsƟ tute of Science and Technology Europe ForschungsgesellschaŌ  mbH (KIST Europe)Campus E 7 1 - 66123 Saarbrücken - Germanyphone + 49 (0) 681 9382 229   -   fax + 49 (0) 681 9382 240hƩ p://www.kist-europe/r_cd_jibb.htmlhƩ p://www.kist-europe.comhƩ p://www.kist-europe.deContact:    PD Dr. Jörg Ingo Baumbach                   Head of Department Microfl uidics and Clinical DiagnosƟ cs                   baumbach@kist-europe.dePart of a IMS-Chromatogram  of human breathR. Cumeras1,2, K. Rupp1, T. Schneider1,3,4, P. Favrod1,5, S. Maddula1, J.I. Baumbach11 KIST Europe, Department Microfl uidics and Clinical DiagnosƟ cs, Campus E 71, 66123 Saarbrücken, Germany2 InsƟ tut de Microelectrònica de Barcelona, IMB-CNM (CSIC). Esfera UAB. Campus UAB s/n. E-08193 Bellaterra (Barcelona) Spain3 ComputaƟ onal Systems Biology Group, Max Planck InsƟ tute for InformaƟ cs. Saarland University, D-66123 Saarbrücken, Germany4 Cluster of Excellence for MulƟ modal CompuƟ ng and InteracƟ on. Saarland University, D-66123 Saarbrücken, Germany5 Haute-Ecole Spécialisée de Suisse Occidentale, HES-SO Valais//Wallis, Route du Rawyl 47, CH-1950 Sion, SwitzerlandAcknowledgementsThe fi nancial support of the Ministry of EducaƟ on, Science and Technology (MEST) of the Republic Korea is acknowledged thankfully. Part of the work on this paper has been supported by Deutsche For-schungsgemeinschaŌ  (DFG) within the CollaboraƟ -ve Research Center (Sonderforschungsbereich) SFB 876 „Providing InformaƟ on by Resource-Constrai-ned Analysis“, project TB1 “Resource-Constrained Analysis of Spectrometry Data“.In addiƟ on, the work was supported partly by the German Federal Ministry of Economics and Tech-nology based on a decision of the German Bundes-tag within the project KF2368102AKO.R. Cumeras gratefully acknowledges support from FPI Fellowship (BES-2008-005267) by the Spa-nish Ministry of Science and InnovaƟ on MICINN-TEC2007-67962-C04-01 project.Room AirStraight ConnectorEndotracheal TubeIon mobility spectro-metry (IMS) – originally used in airports for the detecƟ on of explosi-ves or drugs – can be coupled with a mulƟ -capillary column (MCC) and used for metabolic profi ling, biomarker invesƟ gaƟ on and analysis of hu-man breath. This approach is a sensiƟ ve (pptv-range) and rapid analyƟ cal method to analyse exhaled humid air. Each measurement takes just a few minutes; sample collecƟ on just a few seconds. When samples are measured in a laboratory, which has a cont-rolled environment, it is easy to determine si-gnals that are arising from room air or being associated to the MCC/IMS itself, and those from the sample.Straight ConnectorEndotracheal TubeConnecƟ on to IMSBut when breath analy-sis is carried out in a ‘real-life en-vironment’ such as a hospital, the room air varies leading to a fl uctuaƟ ng number of peaks. In general, the number of uncontrolled sƟ -muli aﬀ ecƟ ng the measurements increases. For ex-ample, in the breath measurement of a paƟ ent under anaesthesia, the hospital devices, connecƟ ons and tubing (like a tracheal tube) could be a source of emission, which were also measured using GC/MS. Also, many volaƟ le or-ganic compounds (VOCs) show signifi cant day-to-day variaƟ on in the signal height, which is related to the concentraƟ on of the analyte. Our results indicate that systemaƟ c and environmental variabili-Ɵ es must be taken into consideraƟ on to relate the outcomes to medical quesƟ ons.

Influence of Room Air and Operational Background Emissions on Breath Analysis Using MCC/IMS

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Influence of Room Air and Operational Background Emissions on Breath Analysis Using MCC/IMS

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