A reactor system with two catalyst beds is proposed for converting methane directly to liquid hydrocarbons. In this dual-bed system, methane is converted in the first stage to oxidative coupling of methane reaction (OCM) products by selective catalytic oxidation with oxygen over a La supported on MgO catalyst. The second bed comprises of a nickel loaded HZSM-5 zeolite catalyst that has been tested as an oligomerization function to convert the OCM products mainly ethylene to liquid hydrocarbons. Thus, the research objective is to establish the factors that exert a greater impact on the dual-bed system and to determine the optimal reaction conditions to achieve the maximum yield of C5+. Three independent factors (temperature (X1), wt% of Ni nickel loading (X2) and methane to oxygen ratio, CH4/02 (X3)) were investigated on the response, yield of C5+ hydrocarbons products (YC5+). These independent variables were coded at three levels and their actual values were selected on the basis of preliminary experimental results. The central composite design (CCD) coupled with response surface methodology (RSM) based on the design of experiments was successfully applied to map the response and to obtain the optimal reaction design. The experimental data was analyzed using an analysis of variance (ANOVA) to determine the significance of the factors tested. Based on the significance of each coefficient, the variable with the largest effect was the quadratic term of temperature, followed by the quadratic term of CH4/02, linear term of Ni wt% and quadratic term of Ni wt%. Numerical results indicated that the optimum C5+ yield of 8.901% was attained at reaction temperature = 742 °C, Ni loading = 0.67 wt% and CH4/02 ratio = 9.68. The model had a satisfactory coefficient of R2 (=0.903) and was verified experimentally. The actual experiment results were in agreement with the prediction. This verification confirmed the validity of the models built, thus indicating the suitability of the model employed and the success of RSM in optimizing the reaction parameters. Furthermore, this optimization strategy led to an increase in the yield of C5+ in the dual- bed system. This exploration also suggests that the concept of this dual catalyst bed system is an interesting candidate for application in methane utilization to produce liquid hydrocarbons
