ACE and ACTN3 Genes Polymorphisms and Endurance Performance: Association Analysis in Young Estonian Male Skiers1401 Board# 194 May 28, 900 AM-1030 AM

Abstract

PURPOSE:(1) To assess ACE gene ACTN3 genotype frequencies in young male skiers compared to the control group and (2) to analyze the relationships between VO 2peak and ACE I/D and ACTN3 R577X polymorphisms in young male skiers. METHODS: Male skiers (n= 56; 14 to 21 yrs), 52% of them are current or former junior national team members of Estonia. A standardized exercise test on a treadmill with determination VO 2peak was performed. Anthropometric measurements and training characteristics were obtained. The male control group (n= 145, 20 to 37 yrs) consisted of healthy sedentary subjects without previous athletic status. Venous blood samples for DNA extraction were collected. Genotyping of rs4343 (ACE, C_11942562_20) and rs1815739 (ACTN3, C_590093_1) was carried out by using the TaqMan SNP 5’allelic discrimination assay. For statistical analysis, descriptive analysis, χ2-test was