The incidence of the population of Russia malignant tumors of maxillofacial region increase every year by 1.53%. Increase of morbidity for the period from 2000 to 2010 is 16.39%. A high level of prevalence can be included to the problem of early diagnosis. Detection of biomarkers in saliva has emerged as a novel approach for the diagnosis of malignant tumors of the oral cavity and its developmental stages including, initial process, invasion, recurrence and treatment
