Gauci, DW

Woods, LM

LSHTM Research Online

Gauci, DW; Woods, LM (2014) Trends in survival of colorectal can-cer in Malta for patients diagnosed from 1995 to 2009 followed up to2010 (poster presentation). In: UNSPECIFIED.Downloaded from: http://researchonline.lshtm.ac.uk/2121471/DOI:Usage GuidelinesPlease refer to usage guidelines at http://researchonline.lshtm.ac.uk/policies.html or alterna-tively contact researchonline@lshtm.ac.uk.Available under license: Copyright the author(s)Trends in colorectal cancer survival – a study among Maltese patients diagnosed  in 1995 to 2009  D. Gaucia, L. Woodsb  aDirectorate for Health Information and Research, Malta bLondon School of Hygiene and Tropical Medicine, UK In Europe; an estimated 446,800 cases of colorectal cancer are diagnosed yearly1.   One of the most common cancers among the elderly – it will remain a major public health concern as the population ages. Aim •Assess trends of colorectal cancer survival in Malta over a 15 year period by the demographic features of the population Population •Maltese residents diagnosed with colorectal cancer from 1995 to 2009 and followed up to end 2010 •2463 participants included in the study (97%) Method •Cohort method for five year relative survival using national cancer registry data and annual population life tables.  •Generalized linear models with a poisson distribution and link function were used to model the collapsed relative survival data2. •  Excess mortality risk ratios calculated as a function of follow up time, year of diagnosis, age at diagnosis, region of residence and gender.  Conclusions  • While improvements have been made in survival over the past 15 years, a gap in survival for older and younger patients remains.  • Improving the knowledge of this target group to increase screening participation will help early diagnosis  • Five year relative survival for all patients is 53.6% (95% CI 51.1 – 56.1).    • Risk ratios show a significant reduction of 17% in risk of mortality for patients diagnosed in 2005 – 2009 compared to those in 1995 –1999 (p=0.024, 95% CI 0.71 – 0.98).    • In the first year of follow up patients aged 55 to 64 have a 1.57 (p=0.003, 95% CI 1.17 – 2.11) greater risk of death when compared to those aged less than 55 while those aged75+ are 2.72 times more likely to die before the end of the first year of follow up(p<0.001, 95% CI;2.05 – 3.6)   • Across all ages, risk of mortality is highest in the first year of follow up. Patients diagnosed at age 75+who survive the first year after follow-up, can expect their relative excess risk of death to drop by 71% in the second year (p<0.001, 95% CI 0.20 – 0.42) Results Key Findings  Reduction in risk of mortality for patients diagnosed in  2005 – 2009 compared to  1995 – 1999  There are no differences by gender and region of residence.  Age at diagnosis and follow up time are significantly associated with excess risk of mortality.  References  1.  Ferlay J, Steliarova-Foucher E, Lortet-Tieulent J, et al. Cancer incidence and mortality patterns in Europe: estimates for 40 countries in 2012. European journal of cancer. 2013;49(6):1374-403. 2.  Dickman PW, Sloggett A, Hills M, Hakulinen T. Regression models for relative survival. Stat Med. 2004 Jan 15;23(1):51-64. 

Trends in survival of colorectal cancer in Malta for patients diagnosed from 1995 to 2009 followed up to 2010 (poster presentation)

http://researchonline.lshtm.ac.uk/2121471/1/Trends%20in%20colorectal%20cancer%20survival%20FINAL%20EUPHA%20poster.pdf

Trends in survival of colorectal cancer in Malta for patients diagnosed from 1995 to 2009 followed up to 2010 (poster presentation)

Abstract

Similar works

Full text

Available Versions

LSHTM Research Online