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Rutin increases the efficacy of temozolomide in glioblastoma via autophagy inhibition

Abstract

Conference Theme: Brain Attack: A New EraPosters: no. P-15The chemotherapeutic agent temozolomide (TMZ) is commonly used in glioblastoma (GBM) therapy, but patients usually have a poor prognosis. Rutin, a citrus flavonoid ecglycoside found in edible plants, has neuroprotection and anticancer activities. This study aims to investigate the efficacy of rutin in combination with temozolomide and the underlying mechanisms. In vitro viability assay demonstrated that rutin alone had generally low cytotoxic effect, but it was able to ...postprin

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