Key Messages 1. Compared with the Hong Kong general population norm, Chinese patients with colorectal neoplasm (CRN) reported worse physical health-related quality of life (HRQOL) but better mental HRQOL and comparable health preference scores. 2. The CRN stage at diagnosis was the most significant determinant of HRQOL. Colorectal cancer was associated with worse physical HRQOL and health preference scores. 3. Immunochemical faecal occult blood testing every 2 years is the most cost-effective colorectal cancer screening strategy, with an incremental cost-effectiveness ratio of HK$43 660 per quality-adjusted life year gained.published_or_final_versio
