The transcription factor Pax7 plays a key role during embryonic myogenesis and in adult organisms in that
it sustains the proper function of satellite cells, which serve as adult skeletal muscle stem cells. Recently
we have shown that lack of Pax7 does not prevent the myogenic differentiation of pluripotent stem cells.
In the current work we show that the absence of functional Pax7 in differentiating embryonic stem cells
modulates cell cycle facilitating their proliferation. Surprisingly, deregulation of Pax7 function also
positively impacts at the proliferation of mouse embryonic fibroblasts. Such phenotypes seem to be
executed by modulating the expression of positive cell cycle regulators, such as cyclin E