GRUPIONI, N. V.

IBELLI, A. M. G.

LEDUR, M. C.

MUNARI, D. P.

PEIXOTO, J. de O.

VENTURINI, G. C.

Repository Open Access to Scientific Information from Embrapa

Session SearchAssociation of the Runt-Related Transcription Factor 2(RUNX2) Gene with Bone Integrity Traits in a PaternalBroiler Line #P642Date: Monday, January 1310:00 am - 11:30 amDescription:Presenters: Natalia Vinhal Grupioni Universidade Estadual Paulista (UNESP),Guilherme Costa Venturini Universidade Estadual Paulista (UNESP), Adriana MérciaGuaratini Ibelli Embrapa Swine and Poultry National Research Center, Jane de OliveiraPeixoto Embrapa Swine and Poultry National Research Center, Monica Correa LedurEmbrapa Swine and Poultry National Research Center, Danísio Prado MunariUniversidade Estadual Paulista (UNESP)P642 - Association of the Runt-Related Transcription Factor 2 (RUNX2) Gene withBone Integrity Traits in a Paternal Broiler LineThe intense selection for rapid growth rate in broilers had favored the onset of locomotorproblems and decreased bone strength of chickens. The Runt-related transcription factor 2(RUNX2) gene is related to the development of bone tissue, acting as a transcription factor inthe formation of osteoblast cells. Mutations on the RUNX2 may result in diseases such ascleidocranial dysplasia. Association analyses between a SNP in the RUNX2 gene and 6 femurintegrity-related traits were performed in a paternal broiler line developed by Embrapa Swineand Poultry National Research Center, Brazil. The evaluated traits in the femur were: weight,length, thickness, breaking force, and dry matter and ash contents. A region of 1044 pb betweenintron 6 and exon 7 of RUNX2 was amplified and genotyped for the g.773 A>G SNP withPCR-RFLP in 562 chickens. Data were analyzed using QxPak software with a mixed modelincluding the fixed effects of sex, hatch and SNP, and the infinitesimal and residuals as randomeffects. Additive, dominant and additive + dominant effects of the SNP were tested includingtheir interaction with sex. The RUNX2 SNP was not associated (p< 0.05) with any of the bonetraits studied. Therefore, it is possible to conclude that the g.773 A>G SNP does not directlyinfluence the traits related to femur integrity measured in this population of broilers.http://pag14.mapyourshow.com/5_0/sessions/sessiondetails.cfm?Sched...1 de 1 27/03/2014 16:43

Association of the Runt-related transcription factor 2 (RUNX2) gene with bone integrity traits in a paternal broiler line.

http://www.alice.cnptia.embrapa.br/alice/bitstream/doc/1014243/1/final7330.pdf

Association of the Runt-related transcription factor 2 (RUNX2) gene with bone integrity traits in a paternal broiler line.

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