BRANDÃO, H. M.

MOSQUEIRA, V. C. F.

PILON, L. E.

SANTANA, R. C. M.

TANAKA, E. V.

ZAFALON, L. F.

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31" WorldVeterinary (ongres5 J 150"Anniv...-sary of the WorldVetennary AssaciatíonPregue. Czern Renubflt 117-20 5eptember2013lD: 124USE OF NANOPARTICULATE AND CONVENTlONAL ANT~M1CROBIALSFORTREATMENT OF SUBCLINICAL MASTlTIS lN SHEEP AT DRYING OFFL. F. Zafalonl, R. C. M. Santana', L. E. Pilon2, H. M. Brandao ', V. C.F. Mosqueira", E. V. Tanaka'I Embrapa Southeast Livestock, Brazilian Agricultural Research Corporation, Sao Carlos, Brazil2 Preventive Veterinary Medicine and Animal Reproduction, Faculty of-;,;lI\gricultural Sciences andVeterinary, São Paulo State University, JaboticabaJ, Brazil3 Ernbrapa Dairy Cattle, Brazilian Agricultural Research Corporation, !ujz de Fora, Brazil4 Department of Pharrnacy.Pederal University of Ouro Preto, Ouro Preto, BrazilTopic: 6. Epidemiology and Infecrious Diseases I Control, Prevention and IrnunoprophylaxisThere are few studies in Braziliah herds about the control merhods for mastins in sheep as there islack of specific producrs for treatrnent of this disease in ewes. The airn of this study is to determinethe efficacy of subcliuieal mastitis treatment immediately before lhe dry period in ewes, as wel! therates of spontaneous recovery in an untrcared control gTOUp, Two antimicrobial formulations, aconventional and a nanoparticulate cloxacillin are being studied. Santa Ines ewes have beendistributed in three groups, considering a 50% prevalence of subclinical mastitis: GI (control); G2(intramammary infusion of 100 mg of cloxacillin); G3 (intramammary infusion of 50 rng ofcloxacillin nanoparticulate). The subclinicalgnastitis was previously diagnosed by California MastinsTest (CMT) and sornatic cell count (SCC), The infectious mastitis was confínned by microbiologicalanalysis before and after treatments likewise all treatments were performed after susceptibility tests invitro. Preliminary results show that infectious subclinical mastitis was idcntified in 44 ewes, Up tonow, coagulase-negative Siaphylococci were lhe most prevalent microorganisms before treatments.SCC before treatment to G l , G2 and G3 were 1,622,000; 1,035,000 and ] 71 ,000 cells/mL and aftertreatrnent were 2,356,000; 1,025,000 and 384,000 cells/ml., respectively, The cure rates were 26.3%to G I; 45.0% to G2; and 60.0% to G3. So far, lhe cure rate for ewes treated by nanoparticulateantimicrobial have been higher than other groups. However, further investigation will be perforrned toevaJuate possible differences among lhe groups and the association of thc cure rates according tornicroorganisms.

Use of nanoparticulate and convencional antimicrobials for treatment of subclinical mastitis in sheep at drying off.

http://www.alice.cnptia.embrapa.br/alice/bitstream/doc/968885/1/USEOFNANOPARTICULATEAND.pdf

Use of nanoparticulate and convencional antimicrobials for treatment of subclinical mastitis in sheep at drying off.

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