Resumen del póster presentado al IX Meeting of the Spanish Society for Developmental Biology celebrado en Granada del 12 al 14 de noviembre de 2012.Peer Reviewe

Culi, Joaquim

Rodríguez-Vázquez, Míriam

Digital.CSIC

Post-translational regulation of lipophorin receptors abstract ID: 83 Main author       Author: Miriam Rodríguez Vázquez  Affiliations       1.- Centro Andaluz de Biología del Desarrollo Authors       (1) Rodríguez Vázquez, Miriam       (1) Culi Espigul, Joaquim   Mammalian Low Density Lipoprotein Receptor (LDLR) proteins are single pass transmembrane proteins involved in multiple processes, most notably lipid metabolism. Drosophila has two genes with homology to the human LDLR known as lipophorin receptor 1 and 2 (lpr1, lpr2) that are essential for neutral lipid uptake by several cell types. Each gene has two alternative promoters (P and D) that give rise to multiple isoforms (P- and D-isoforms) having strikingly different functions and distributions. These isoforms are subjected to differential post-translational regulation when expressed in imaginal discs affecting their subcellular distribution and activity. We have mapped the protein domains required for this post-translational regulation to the signal peptide characteristic of P-isoforms. We are currently studying how the signal peptide affects protein stability and function. In mammals, the E3-ubiquitin ligase IDOL regulates the LDLR post-translationally promoting its degradation. Our data indicates that a Drosophila IDOL distant homolog, known as defense repressor 1, is also critical for the regulation of the Lipophorin Receptors. Our work reveals the functional relevance of isoform-specific post-translational regulation of LDLR proteins.                 130 ·BACK TO INDEX

Post-translational regulation of lipophorin receptors

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