Resumen del trabajo presentado al IX Meeting of the Spanish Society for Developmental Biology celebrado en Granada del 12 al 14 de noviembre de 2012.Peer Reviewe

Gómez-Skarmeta, José Luis

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Genomic architecture, gene regulation and human diseases Thematic area:Developmental Genomics Main author       Author: Jose Luis Gómez Skarmeta  Affiliations       1.- Centro Andaluz de Biología del Desarrollo  Authors       (1) Gómez Skarmeta, Jose Luis   The generation of distinctive cell types that form different tissues and organs requires precise, temporal and spatial control of gene expression. This depends on specific cis-regulatory elements distributed in the non-coding DNA surrounding their target genes that became active or inactive at particular developmental stages. On the top of this, the 3D structure of the chromatin plays an essential role in facilitating the access of such cis-regulatory elements to particular promoters.  In this seminar, I will discuss the importance of the chromatin architecture and the dynamic of cis-regulatory elements during development and its implication in human diseases and genome evolution.    17 ·BACK TO INDEX

Genomic architecture, gene regulation and human diseases

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