Retinoic acid is a widely used drug in the treatment of cystic acne.
It has teratogenic effects that depend on the gestational period in which it is used. We report a
seven months old female whose mother was exposed to retinoic acid in both pregestational and
gestational periods. She had a retardation of psychomotor development and a brain MRI
showed frontal atrophy and a malformation of the posterior fossa. We discuss the mechanisms
of the teratogenic effects of retinoic aci
