David, Helga Susana Moreira

Durhuus, Thomas Thomasen

Förster, Jochen

Katz, Michael

Petersen Bjørn, Sara

Schmidt, Hans Peter

Sendelius, Malin

A genetically engineered micro-organism having an operative metabolic pathway producing cinnamoyl-CoA and producing pinosylvin therefrom by the action of a stilbene synthase is used for pinosylvin production. Said cinnamic acid may be formed from L-phenylalanine by a L-phenylalanine ammonia lyase (PAL) which is one accepting phenylalanine as a substrate and producing cinammic acid therefrom, preferably such that if the PAL also accepts tyrosine as a substrate and forms coumaric acid therefrom, the ratio Km(phenylalanine)/Km(tyrosine) for said PAL is less than 1:1 and if said micro-organism produces a cinammate-4- hydroxylase enzyme (C4H), the ratio Kcat(PAL)/Kcat(C4H) is at least 2:1

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Metabolically engineered cells for the production of pinosylvin

http://orbit.dtu.dk/ws/files/103262987/WO2008009728A1.pdf

Metabolically engineered cells for the production of pinosylvin

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