Kinetic modelling of binding between monoclonal antibodies and the FcγRIIIa receptor

Abstract

Mathematical modelling is becoming an increasingly important part of life sciences. This thesis deals with a mechanistic biological model of binding between two kinds of antibodies and the FcγRIIIa receptor. Our goal was to develop a method that would determine the model parameters to match experimental data. The best method turned out to be the Levenberg-Marquardt algorithm, which is surprisingly reliable and fitted the model to the data well. The results give us an estimate of important physical parameters of the antibody that can be useful in the characterization of a biopharmaceutical drug