Povezanost polimorfizma gena za kemokine CXCL9 i CXCL10 s pojavom akutnog odbacivanja jetrenoga presatka [Association between CXCL9 and CXCL10 chemokine gene polymorphisms and acute graft rejection after liver transplantation]

Abstract

Acute cellular rejection (ACR) is a clinically important event that negatively affects the survival of the graft and the recipient. As potent T cell- chemoattractants, CXCL9 and CXCL10, have been demonstrated to play a central role in the immune response against transplant tissue, leading to ACR. While increased serum concentrations of CXCL9/10 are associated with ACR occurrence, the association between CXCL9/10 single nucleotide polymorphisms (SNPs) and ACR after liver transplantation (LT) remains unknown. SNPs of CXCL9 (rs10336) and CXCL10 (rs3921) were determined by polymerase chain reaction in 215 recipients transplanted due to alcoholic cirrhosis with or without hepatocellular carcinoma. 27.4% recipients were diagnosed with ACR that was defined as biopsy-proven within 6 months after LT. Recipients that developed ACR had significantly higher MELD scores pre-LT and received significantly younger liver grafts. There was no association between CXCL9/10 genotypes and overall incidence of ACR, the severity of ACR and the number of rejection episodes. However, patients with CXCL9 genotype AA developed ACR earlier, suggesting the involvement of CXCL9-mediated processes in ACR development