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Topoisomerase inhibitors: Pharmacology and emerging nanoscale delivery systems
Authors
M. Ashrafizadeh
A. Dehshahri
+5 more
E. Ghasemipour Afshar
A. Mandegary
R. Mohammadinejad
A. Pardakhty
G. Sethi
Publication date
1 January 2020
Publisher
Abstract
Topoisomerase enzymes have shown unique roles in replication and transcription. These enzymes which were initially found in Escherichia coli have attracted considerable attention as target molecules for cancer therapy. Nowadays, there are several topoisomerase inhibitors in the market to treat or at least control the progression of cancer. However, significant toxicity, low solubility and poor pharmacokinetic properties have limited their wide application and these characteristics need to be improved. Nano-delivery systems have provided an opportunity to modify the intrinsic properties of molecules and also to transfer the toxic agent to the target tissues. These delivery systems leads to the re-introduction of existing molecules present in the market as novel therapeutic agents with different physicochemical and pharmacokinetic properties. This review focusses on a variety of nano-delivery vehicles used for the improvement of pharmacological properties of topoisomerase inhibitors and thus enabling their potential application as novel drugs in the market. © 2019 Elsevier Lt
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Simorgh Research Repository
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oai:eprints.kmu.ac.ir:33276
Last time updated on 08/04/2021
Simorgh Research Repository
See this paper in CORE
Go to the repository landing page
Download from data provider
oai:eprints.kmu.ac.ir:37750
Last time updated on 16/05/2022