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A review: Recent advances in ultrasensitive and highly specific recognition aptasensors with various detection strategies
Authors
Z. Aramesh-Boroujeni
F. Borhani
+7 more
N. Ebrahimpour
L.K. Foong
M.M. Foroughi
S. Jahani
N. Rezaei Zade Baravati
M. Safaei
S.-R. Yan
Publication date
1 January 2020
Publisher
Abstract
One of the most studied topics in analytical chemistry and physics is to develop bio-sensors. Aptamers are small single-stranded RNA or DNA oligonucleotides (5�25 kDa), which have advantages in comparison to their antibodies such as physicochemical stability and high binding specificity. They are able to integrate with proteins or small molecules, including intact viral particles, plant lectins, gene-regulation factor, growth factors, antibodies and enzymes. The aptamers have reportedly shown some unique characteristics, including long shelf-life, simple modification to provide covalent bonds to material surfaces, minor batch variation, cost-effectiveness and slight denaturation susceptibility. These features led important efforts toward the development of aptamer-based sensors, known as apta-sensors classified into optical, electrical and mass-sensitive based on the signal transduction mode. This review provided a number of current advancements in selecting, development criteria, and aptamers application with the focus on the effect of apta-sensors, specifically for disease-associated analyses. The review concentrated on the current reports of apta-sensors that are used for evaluating different food and environmental pollutants. © 2020 Elsevier B.V
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Simorgh Research Repository
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oai:eprints.kmu.ac.ir:32900
Last time updated on 16/05/2021
Simorgh Research Repository
See this paper in CORE
Go to the repository landing page
Download from data provider
oai:eprints.kmu.ac.ir:37313
Last time updated on 16/05/2022