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EMT signaling: potential contribution of CRISPR/Cas gene editing
Authors
A.R. Aref
G. Arunkumar
+11 more
I. Azimi
A. Biagioni
K.-C. Chang
M. Hashemabadi
A. Mandegary
R. Mohammadinejad
A. Pardakhty
M. Sedeeq
R. Shapiro
A. Taiyab
J.-P. Thiery
Publication date
1 January 2020
Publisher
Abstract
Epithelial to mesenchymal transition (EMT) is a complex plastic and reversible cellular process that has critical roles in diverse physiological and pathological phenomena. EMT is involved in embryonic development, organogenesis and tissue repair, as well as in fibrosis, cancer metastasis and drug resistance. In recent years, the ability to edit the genome using the clustered regularly interspaced palindromic repeats (CRISPR) and associated protein (Cas) system has greatly contributed to identify or validate critical genes in pathway signaling. This review delineates the complex EMT networks and discusses recent studies that have used CRISPR/Cas technology to further advance our understanding of the EMT process. © 2020, Springer Nature Switzerland AG
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Simorgh Research Repository
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oai:eprints.kmu.ac.ir:32923
Last time updated on 16/05/2021
Simorgh Research Repository
See this paper in CORE
Go to the repository landing page
Download from data provider
oai:eprints.kmu.ac.ir:37347
Last time updated on 16/05/2022