Empyema necessitans (also called empyema necessitatis) is a sequelae of empyema/parapneumonic effusion where infection progresses beyond the pleural space into the soft tissues of the chest wall. Typical pathogens includeMycobacterium tuberculosis,Streptococcus pneumoniae, andStaphylococcus aureus. Fungal empyema necessitans is uncommon, with the majority of cases secondary to Candida species. We report a rare and fatal case of empyema necessitans presenting in a patient with cystic fibrosis more than 10 years following double-lung transplant.</jats:p