Kurze, Christoph

Le Conte, Yves

Dussaubat, Claudia

Mueller, Thomas

Kryger, Per

Erler, Silvio

Moritz, Robin

Lewkowski, Oleg

English

Sydney eScholarship

 OR350 Escaping parasite manipulation: Apoptosis and host-parasite co-evolution in Apis mellifera Christoph Kurze, Yves Le Conte, Claudia Dussaubat, Thomas Mueller, Per Kryger, Silvio Erler, Robin Moritz   Programmed cell death (apoptosis) does not only play an important role in the development of multicellular organisms, but also in the protection against pathogens. Nevertheless, numerous intracellular pathogens have evolved diverse strategies to interfere with and overcome the apoptotic machinery of their hosts. Yet, little is known about the actual mechanisms and how hosts might counter act. We here study the interaction of the intestinal microsporidian parasite Nosema ceranae in a susceptible and tolerant honeybee host under laboratory controlled conditions, to understand the importance of apoptosis in this case of host-parasite co-evolution. We visualize apoptotic processes in the gut epithelium using TUNEL assays; relate this to the expression levels of key genes in the apoptotic cascade over the course of the infection, and consequences for metabolic energetics affecting honeybee performance.

Escaping parasite manipulation: Apoptosis and host-parasite co-evolution in Apis mellifera

Boekel, G.A.J van

NARCIS 

Optimizing immunosuppressive therapy after renal transplantation

https://ses.library.usyd.edu.au/bitstream/2123/11053/2/OR350.pdf

Escaping parasite manipulation: Apoptosis and host-parasite co-evolution in Apis mellifera

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