Si tratta di un laboratorio attraverso il quale il pubblico può calcolare la magnitudo di un ipotetico terremoto

Cheneval, Olivier

Craik, David

Dantas de Araujo, Aline

Fairlie, David

Huang, Yen-Hua

Lawrence, Nicole

Philippe, Gregoire

Troeira Henriques, Sonia

Zhang, Zhen

The transcription factor p53 has a tumor suppressor role in leading damaged cells to apoptosis. Its activity is regulated/inhibited in healthy cells by the proteins MDM2 and MDMX. Overexpression of MDM2 and/or MDMX in cancer cells inactivates p53, facilitating tumor development. A 12-mer dual inhibitor peptide (pDI) was previously reported to be able to target and inhibit MDMX:p53 and MDM2:p53 interactions with nanomolar potency in vitro. With the aim of improving its cellular inhibitory activity, we produced a series of constrained pDI analogs featuring lactam staples that stabilize the bioactive helical conformation and fused them with a cell-penetrating peptide to increase cytosol delivery. We compared pDI and its analogs on their inhibitory potency, toxicity, and ability to enter cancer cells. Overall, the results show that these analogs keep their nanomolar affinity for MDM2 and MDMX and are highly active against cancer cells

Queensland University of Technology ePrints Archive

Development of cell-penetrating peptide-based drug leads to inhibit MDMX:p53 and MDM2:p53 interactions

Solarino, S

Eva, E

Earth-prints Repository

distanza
Magnitudo Ampiezza
Calcolare la magnitudo è semplice come...usare un righello. Ecco cosa devi
fare. Individua le onde P e le onde S sul sismogramma. Le riconosci perché
sono rispettivamente il punto dove inizia la registrazione (dove la linea non è più
diritta, per capirci) e il punto dove l’ampiezza della traccia aumenta. Ricorda che
il sismogramma va da sinistra verso destra.
Adesso “conta” quanti secondi differenziano le due onde, e riporta il valore sulla
colonna a sinistra. Così facendo avrai anche individuato una stima della
distanza dall’epicentro. Poi misura l’ampiezza più grande del sismogramma e
riportala sulla colonna a destra. Unisci i punti con una righetta e leggi la
magnitudo sulla colonna centrale.
Quanto vale?
Tempo in secondi (ogni tacca un secondo)
5 10 15
Stefano Solarino, Elena Eva. INGV.
Creative commons


Calcolare la magnitudo è semplice!

The transcription factor p53 has a tumor suppressor role in leading damaged cells to apoptosis. Its activity is regulated/inhibited in healthy cells by the proteins MDM2 and MDMX. Overexpression of MDM2 and/or MDMX in cancer cells inactivates p53, facilitating tumor development. A 12-mer dual inhibitor peptide (pDI) was previously reported to be able to target and inhibit MDMX:p53 and MDM2:p53 interactions with nanomolar potency in vitro. With the aim of improving its cellular inhibitory activity, we produced a series of constrained pDI analogs featuring lactam staples that stabilize the bioactive helical conformation and fused them with a cell-penetrating peptide to increase cytosol delivery. We compared pDI and its analogs on their inhibitory potency, toxicity, and ability to enter cancer cells. Overall, the results show that these analogs keep their nanomolar affinity for MDM2 and MDMX and are highly active against cancer cells. © 2016 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 106: 853-863, 2016

Fairlie, David P.

Craik, David J.

Dantas De Araujo, Aline

University of Queensland eSpace

Grégoire Philippe

Yen‐Hua Huang

Olivier Cheneval

Nicole Lawrence

Zhen Zhang

David P Fairlie

David J. Craik

Aline Dantas de Araujo

Sónia Troeira Henriques

Crossref

Biopolymers

Development of cell‐penetrating peptide‐based drug leads to inhibit MDMX:p53 and MDM2:p53 interactions

http://www.earth-prints.org/bitstream/2122/8537/1/magnitudol.pdf

Calcolare la magnitudo è semplice!

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Queensland University of Technology ePrints Archive

Earth-prints Repository

University of Queensland eSpace

Crossref